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Vitiligo usually begins on the hands, forearms, feet, and face, but it can develop anywhere on the body, including the mucous membranes (the moist lining of the mouth, nose, genitals, and rectum), the eyes, and the inner ear

found that the mechanism of selenium inhibition of tumor cell cycle progression may be related to selenium regulation of RNA expression of mitotic cell cycle protein B and cdc2 kinase activity by analyzing the cell cycle effects of selenoethanethionine in colon cancer cells in their laboratory (157)

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Zero DT et al (2016): Clinical practice guidelines for oral management of Sjgren disease: Dental caries prevention