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Meanwhile, correlation analysis between MANF level and clinical variables in ICC showed that high expression of MANF was associated with larger tumor diameter ( P = 0.026), TNM stage ( P = 0.000), and distant metastasis ( P = 0.017) (Supplementary Table 1)

3.3.1 The RSS-cysteine-GSH metabolic axis as a regulatory triad RSS regulation of DC function operates primarily through control of cysteine availability and GSH homeostasis, rather than solely through H 2 S signaling

Previous studies have shown reduced CORT during breastfeeding 56 and that breastfeeding women have a lower HPA response to exercise stress than bottle-feeding women 52

alterations in mood, including depression and anxiety