interaction of chloroacetamide electrophiles with cellular glutathion NCBP1 stress signaling drives alternative S6K1 splicing inhibiting translation Discovery of novel benzylaniline derivatives

Discovery of novel benzylaniline derivatives containing chloroacetamide as GPX4 inhibitors with potential efficacy in triple negative breast cancer ScienceDirect Selective covalent targeting of GPX4 using masked nitrile oxide electrophiles Nature Chemical Biology Electrophilic compound screening identifies GPX4 dependent ferroptosis as a senescence vulnerability Nature Cell Biology Glutathione Dynamics in Subcellular Compartments and Implications for Drug Development PMC

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