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Le stress: Le stress chronique peut puiser les rserves de glutathion

In some studies, the 5-lipoxygenase inhibitor zileuton, when co-administered with PGE2, reduced pulmonary bacterial burden and pathology and prevented acute death in M.tb -infected mice deficient in both IL1R1 and IFNAR1 [129]

doi: 10.1016/j.cmi.2018.03.009 [DOI] [PubMed] [Google Scholar] Koetsveld J, Kolyasnikova NM, Wagemakers A, Toporkova MG, Sarksyan DS, Oei A, Platonov AE, and Hovius JW (2017b)

On the other hand, its high reactivity also contributes to the uncontrolled removal of electrons, which underlies pathological cell damage through the propagation of highly reactive oxygen-containing molecules