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Prior to the specification of the sclerotome, the somites are derived from the paraxial mesoderm through the inhibition of bone morphogenetic protein (BMP) signaling in the lateral plate mesoderm by follistatin, an activin-binding protein, working in tandem with Noggin (Stafford et al., 2014)

Contrasting Preclinical Promise with Human Data The central challenge for clinicians is the stark contrast between the vast, overwhelmingly positive body of preclinical BPC-157 evidence and the near-total absence of published, peer-reviewed human clinical trials

The risk of adverse effects is very low

Reference lists of included articles and relevant reviews were manually screened to identify additional pertinent studies