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10.1016/j.chembiol.2020.02.005 96 LiuP.FengY.LiH.ChenX.WangG.XuS.et al (2020b)

This is related to the consequent activation of cyclooxygenase-II in peritoneal monocytes

However, metformin inhibits mitochondria in a dose-dependent manner and at high doses, although it is able to impair tumor growth, it may also lead to lactic acidosis (116)