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Targeting the PPAR/PGC-1-CPT1A axis, lipid receptors (CD36/KIM-1), and inflammasome signaling, along with the intestinal flora and other regulatory targets, represent promising new strategies for delaying RF

One mechanism by which adipocytes promote resistance is through pyroptosis-induced lipid release, wherein dying adipocytes liberate free fatty acids that are then taken up by adjacent tumor cells and provide a metabolic substrate that supports survival and reduces platinum sensitivity [138]

Hair researchers have noted the accumulation of such fat around healthy follicles that are vigorously growing hair and its relative lack around dormant follicles

In an acute lung injury model using mice, bacterial migration from lungs to intestines via blood circulation resulted in increased microbial load within the intestines leading to disruption of gut microbiota diversity (34)