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The story focused on how milder tobacco, such as the varieties grown in Cyprus, contained less nicotine and were less strong than other tobacco, and that cigarettes with Cypriot tobacco should be encouraged for women and men alike because of its mild and delicate properties.Footnote 170 The allusion to milder cigarettes being healthier indicates some early consciousness that harsher cigarettes containing more nicotine might be harmful

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This clearance mechanism has also been described in the context of different cellular stressors leading to PS exposure, e.g., hyperosmotic stress [217], plasmodium infection [77], oxidative stress [72], and, to some extent, also ageing of erythrocytes [218]