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have shown that the potent inhibitory effect of TGF-1 on gamma-glutamylcysteine synthetase inhibits the synthesis of GSH in the lung epithelial cell line A549 [49]

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Thus, the observed formation of MeHg-hCys complexes at near physiological conditions of blood plasma provides a feasible pathway by which MeHg + is delivered to the brain (Figure 2), where adverse biochemical processes including the inhibition of the selenoprotein glutathione peroxidase 4 (GPx) will then unfold (Chen et al., 2023)