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In an intriguing approach, a phase I study has investigated the combination of carboplatin with paclitaxel injection concentrate for nano-dispersion (PICN) in patients with advanced solid malignancies (ClinicalTrials.gov Identifier: NCT01304303) [25]

111 Once the hits were obtained, structure-activity relationship (SAR) optimization in synergistic application of computational methodologies such as fragment-growing, property prediction, and MD simulations, was conducted to initiate the hit-to-lead and lead-to-drug campaign

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About one-third of collagen's composition consists of glycine molecules arranged in repeating sequences