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The bovine and human models (1GP1 and 2F8A respectively) were chosen for this study given their mammalian origin and amino acid sequence similarity (87.4%)

Age was different between groups in cohort 1, but not in cohort 2

Cardiolipin represents around 1015% of mitochondrial membrane phospholipids and promotes the formation of mitochondrial cristae (Joubert and Puff, 2021), Cardiolipin also interacts with numerous other proteins involved in protein import, calcium transport, and cell death (Ghosh et al., 2020) (Figure 3)

Anakinra, a kind of IL-1 receptor antagonist that blocks activity of both IL-1 and IL-1, has been approved by the FDA and the EDA (European Drug Administration) for the treatment of rheumatoid arthritis, systemic-onset juvenile idiopathic arthritis, and familial Mediterranean fever (, , )