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To induce mitochondrial mistranslation, we used the peptide mimetic actinonin (ACT) resulting in the accumulation of mistranslated, membrane-inserted mitochondrial proteins causing subsequent membrane potential loss 16,17,18,19,20,21

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Similarly, studies on mouse models have revealed that after using neomycin sulfate, clearance of sensitive intestinal bacteria increases susceptibility to influenza virus infection in lungs (24, 155), and antibiotic use may lead to dysbiosis in gut microbiota communities which increases mortality risk due to bacterial infections (26)

Key metabolites of the kynurenine pathway (KP), such as kynurenine (KYN), act as agonists for the aryl hydrocarbon receptor (AHR)