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Description

The approval was supported by data from the Phase III PRECISION trial, where both the 12.5-mg and 25-mg dose levels of Tryvio significantly reduced sitting systolic blood pressure compared with placebo after four weeks of treatment

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DXN-induced chemobrain is known to result in significant changes in oxidative stress biomarkers in the brain, including elevated levels of ROS, lipid peroxidation, and MDA, and reduction in endogenous antioxidants such as SOD and GPx as well as mitochondrial function ( The mortality rate serves as a vital metric in evaluating the risk associated with drug toxicity

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The underlying mechanism of this phenomenon remains unclear

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