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Effect of thiols on the reductive activation rate

(2) Saponins: Astragaloside IV, an active component of Astragalus, activates the PI3K/AKT and Nrf2 signaling pathways, reduces oxidative stress, enhances GPX4 and Nrf2 expression, reduces iron accumulation, inhibits ferroptosis induced by Aflatoxin, significantly improves kidney damage, and protects kidney cells (178)

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Astrocytic epigenetic state transitions Astrocytes exhibit functional changes, partly regulated by epigenetic reprogramming in the pathogenesis of AD