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3 Metabolic reprogramming related to ferroptosis in OA Having established the significance of ferroptosis in OA pathology, we now turn our attention to how metabolic reprogramming involving lipids, amino acids, iron, and glucose underpins ferroptotic susceptibility

doi: 10.1016/j.bcp.2021.114693 Redd, Meredith A., Scheuer, Sarah E., Saez, Natalie J., Yoshikawa, Yusuke, Chiu, Han Sheng, Gao, Ling, Hicks, Mark, Villanueva, Jeanette E., Joshi, Yashutosh, Chow, Chun Yuen, Cuellar-Partida, Gabriel, Peart, Jason N., See Hoe, Louise E., Chen, Xiaoli, Sun, Yuliangzi, Suen, Jacky Y., Hatch, Robert J., Rollo, Ben, Xiao, Di, Alzubaidi, Mubarak A.H., Maljevic, Snezana, Quaife-Ryan, Gregory A., Hudson, James E., Porrello, Enzo R., White, Melanie Y., Cordwell, Stuart J., Fraser, John F., Petrou, Steven, Reichelt, Melissa E

Global Environ

For example, glutathione can easily attach and detach from other glutathione molecules and other proteins that have this functional group