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Gao Z, Zhang Z, Gu D, Li Y, Zhang K, Dong X

10.1002/smll.202201300 16 ChenJ

These double mutants were purified and tested against four non-native substrates

Notably, muscle creatine levels showed a consistent inverse correlation with the severity of myalgia, suggesting that creatine depletion may contribute to impaired ATP buffering, mitochondrial dysfunction, and symptom burden