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BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

In addition, in the fibroblast-derived cell lines BJ-TERT, BJ-TERT/LT/ST, and BJ-TERT/LT /ST/RAS V12 (HRAS activated), it was found that the mRNA expression of TfR1 increased gradually in these three cell lines

J Internal Med

For example, Legionella pneumophila secretes the effector SdhA, which maintains mitochondrial integrity and limits mtDNA leakage, helping the bacterium to avoid immune hyperactivation ( Beyond the cGAS-STING and NLRP3 inflammasome pathways, mtDNA also serves as a ligand for endosomal TLR9, which recognizes unmethylated CpG motifs in bacterial and mitochondrial DNA (Tripathi et al., 2023)