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therefore, it must be transported into the cells by SLC7A11 (xCT) in exchange for glutamate, which implies that SLC7A11-mediated GSH biosynthesis largely relies on glutamine metabolism 55

thaliana with 128 ABC genes contains the highest number of genes encoding for ABC transporters compared to other systems, among them 22 members of the MDR, 15 members of the MRP, and 13 members of the PDR family have been annotated ( The involvement of MRP subfamily of ABC transporters (also known as MRP/ABCC and GSH S -conjugate pump) in the transport of glutathionylated anthocyanins has been originally reported in maize and petunia ( Arabidopsis ( O -glucosides can be transported into microsomes of yeast expressing MDR from grapevine by co-transporting GSH ( More on the transport processes in flavonoid biosynthesis has been ensured due to analysis of Arabidopsis tt mutants known to be defective in flavonoid biosynthesis ( tt12 exhibits pigment deficiency in the seed coat due to the lack of vacuolar deposition of Pas (Zhao and Dixon, 2009)

Therefore, ferroptosis inducers may constitute an attractive strategy for thyroid cancer treatment

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