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Clinically, melatonin has been reported to reduce the risk of hemorrhagic transformation after tissue plasminogen activator (t-PA) therapy in ischemic stroke (150, 151), suggesting a potential role in improving thrombolytic safety through modulation of BBB permeability

Another commonly used expression for the Lindemann criterion is [20] From the expression for the Debye frequency for , where D is the Debye temperature and h is the Planck constant

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