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Description

The reaction also produces 5-methyl-THF

Upon encountering an unfavorable stimulus, unfolded or incorrectly folded proteins have the ability to activate the unfolded protein response (UPR) signaling pathway, which then transports them out of the ER where they are degraded by the proteasome (173, 174)

Nat Commun 10(1):3143 Oh G, Wang A, Wang L et al (2023) POLQ inhibition elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma via cGAS/STING signaling