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Although to date some of these have been used to assist the identification of small molecules 5,7,21 , none has directly probed druggable pockets on RAS, as the majority of these biologics tend to bind over large protein interfaces 14,15,17,20 that are difficult to mimic with small molecules 22

Tuy nhin s thiu ht ca 2 loi protein ny trong c th s thc y qu trnh lo ha da din ra nhanh chng, vi cc biu hin m chng ta c th nhn thy c nh tnh trng trng da, chy x, xut hin np nhnTrong khi GSH c chng minh l c kh nng d tr collagen v elastin, nh vy cc t bo da b h tn s c c hi c sa cha, phc hi

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