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By disrupting the methylation and metabolic pathways, these targeted drugs not only directly induce tumor cell death but also indirectly alleviate the immunosuppression driven by epigenetics and metabolism, thereby reshaping the microenvironment to support anti-tumor immunity [132, 133]

Front Psychol 10:53 Zaitone SA, Abo-Elmatty DM, Shaalan AA (2012) Acetyl-L-carnitine and alpha-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinsons disease therapy

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