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Constipation is not listed as a side effect in UK product information, and as a water-soluble vitamin, excess B12 is excreted through urine rather than causing gastrointestinal effects

The addition of the reverse transcription buffer (Invitrogen), 0.5 mM dNTPs (Takara, Shiga, Japan), 40 U of RNase-inhibitor (Roche, USA), and 200 U of SuperScript II reverse transcriptase (Invitrogen, Waltham, MA, USA) was used for the first strand of cDNA synthesis

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Quick Answer: Increased urination on tirzepatide typically results from improved blood sugar control, temporary fluid shifts during weight loss, concurrent medications, or increased water intake rather than being a direct drug side effect