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Neuropsychopharmacology 37(9):21432152 Schulte M, Goudriaan A, Kaag A, Kooi D, van den Brink W, Wiers R et al (2017) The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: a randomized, double-blind, placebo-controlled trial

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If visible rubber fragments appear in the vial contents after a draw, the documented standard is to discard the vial regardless of remaining volume or days left in the window