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Exposure to UV light and atmospheric oxygen generates reactive oxidative species that convert tryptophan's indole ring into oxidized products (kynurenine pathway derivatives and others)

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Lim YY, Hassenstab J, Cruchaga C, Goate A, Fagan AM, Benzinger TL, et al

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By preserving SAM, NNMT inhibition may restore normal epigenetic control of metabolic gene expression in fat cells

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