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The leaf extracts exhibit diuretic effects similar to furosemide, but with the added benefit of maintaining K + levels (509)

Well-documented adult consequences of B12 deficiency include pernicious anemia, megaloblastic anemia, peripheral neuropathy neuropsychiatric syndromes and subacute combined degeneration of spinal cord [2,3,4]

Costimulation, particularly via CD28, is crucial for T cell-dependent NF-B activation, which occurs through the induced membrane recruitment and enzymatic activity of PKC and PDK1 (81) ( Figure 2 )

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