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and c) comparing the amount or activity of the at least one target listed in table 1 and/or table 2 detected in steps a) and b), wherein the absence or reduction in the copy number, amount and/or activity of the at least one target listed in table 1 and/or the presence or increase in the copy number, amount and/or activity of the at least one target listed in table 2 in monocytes and/or macrophages from subsequent samples compared to the copy number, amount and/or activity of monocytes and/or macrophages from the first sample is indicative that the subject's monocytes and/or macrophages have an up-regulated inflammatory phenotype

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