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This observation can be explained by the threshold effect of SDS concentration introduced by Manalastas, indicating that higher concentrations and longer exposure times do not necessarily translate into better outcomes, supported in our prior study, showing significant loss of mechanical properties, including GAG reduction, impaired collagen integrity, and altered ECM interactions after a gradual increase in SDS concentrations 36

We treated cells with both iHAP1 [16], a PP2A agonist, and LB-100 [17], an inhibitor of PP2A, and showed that iHAP1 mediated the activation of PP2A mitigated hypoxia-induced neuronal death (Supplemental Fig

And its effective when directly injected into the brain or via nasal spray

Peptide therapy refers to treatments that use amino-acid chains to stimulate biological processes such as tissue repair, hormone production, and metabolism regulation