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What The Science Says 2025 human studies have shown that dietary doses of TMG (0.52 g/day) can acutely lower homocysteine sometimes by as much as 20% with high doses (46 g/day) used therapeutically to reduce homocysteine spikes after methionine intake.1 This action underpins its emerging role in longevity research, where efficient methylation and homocysteine regulation are seen as pillars of cellular health

Although inexpensive and easy to carry out, this method is only able to detect cases with 20% or less of mean normal G6PD activity and misses most of the moderate G6PD activity especially in female heterozygotes (4)

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