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(3) Alkaloids: Nelumbine, a bioactive alkaloid isolated from lotus leaf, exhibits strong antioxidant properties and targets the suppression of folate-induced ferroptosis-related renal pathological changes by regulating the levels of GPX4, SLC7A11, and FSP1

The antibody-drug conjugate according to any one of claims 1-5 wherein L is a cleavable linker moiety of formula -A-W-, wherein A is an optional stretcher unit linked to Ab, and W is a cleavable moiety linked to D

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Moreover, anti-A treatment at very early stages of development had positive outcomes in mouse models of -amyloidosis