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Freezing can cause the proteins to denature, rendering the medication ineffective

doi: 10.1146/annurev.med.56.082103.104546 126 PoppHDNaumannNBrendelSHenzlerTWeissCHofmannWKet al

JACC Heart Fail 2015;3:212-213

Moreover, such biochemical and cellular effects can contribute on a larger scale to disturbances in food chains, reduction of biodiversity, and the compromise of the functional structure of aquatic ecosystems (Hong et al., 2015