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Additionally, mitochondrial-derived peptide-c (MOTS-c) has been shown to reverse mitochondrial dysfunction and reduce oxidative stress, thereby alleviating metabolic reprogramming, decreasing beta-oxidation, and increasing glycolytic flux influenced by abnormal metabolism during myocardial infarction [464]

Abstract Inherited Metabolic Diseases (IMD) encompass a diverse group of rare genetic conditions that, despite their individual rarity, collectively affect a substantial proportion, estimated at as much as 1 in 784 live births

Systolic blood pressure declined by 9.9 mm Hg with the combination and 3.2 mm Hg with placebo (-6.7 mm Hg difference

the approach should be individualized, symptom-based and stepwise, establishing shared goals with the patient