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Preclinical euglycaemic clamp data showed no impairment of insulin sensitivity at therapeutic doses

J Gen Physiol 118:4562 Liantonio A, Accardi A, Carbonara G, Fracchiolla G, Loiodice F, Tortorella P et al (2002) Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-( p -chlorophenoxy)propionic acid

IFN- acts on the IFN- receptor, resulting in the phosphorylation of JAK1/2, which triggers the phosphorylation of STAT1 and leads to an increase in interferon regulatory factor 1 (IRF1) expression, which inhibits the function of SLC7A11 with SLC3A2 (system Xc ), ultimately leading to ferroptosis (61)

doi: 10.1016/j.cell.2021.05.039 204 HilliganKLNamasivayamSClancyCSOMardDOlandSDRobertsonSJet al