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Sevigny et al., 2016)

Heme-oxygenase (HO)-1 is one of the targets of Nrf2 and facilitates the degradation of heme, leading to the generation of carbon monoxide (CO) and the release of free iron, ultimately reducing the overall production of ROS (47)

CYP2E1 promoter methylation levels were higher in toluene-exposed smokers compared to non-smokers, and were also correlated with GSTP1 and SOD1 promoter methylation