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Funding The work was supported by the National Natural Science Foundation of China (No.82000572, 82073914, 82173874, 82274185), the Natural Science Foundation of Jiangsu Province (No.BK20220467, BK20200840), the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions (No.22KJB310013, 19KJA310005), the Joint Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica and Yangtze River Pharmaceutical (No.JKLPSE202005), the Natural Science Foundation of Nanjing University of Chinese Medicine (No.NZY82000572), Nanjing Pharmaceutical Association-Changzhou Fourth Pharmaceutical Hospital Pharmaceutical Research Fund (NO.2021YX030), and Postgraduate Research & Practice Innovation Program of Jiangsu Province (No