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Oksenberg A

Per 200 ng/dL of increased testosterone, bone density increased by 6.1% in deficient older men, but arterial plaque formation was also noted

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Finally, key disease phenotypes of the Mmut p.L690Ins/p.L690Ins mice, such as weight loss, were not rescued by BCATi, in contrast with complete rescue in response to replacement of the defective Mmut gene with the normal human MMUT gene via an AAV construct, as shown here and previously in other murine MMA models (37)