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Investigations have focused on its receptor activity, signaling mechanisms, and applications in controlled dermatological research models

TNFAIP3, an inhibitor of NF-B activation and TNF- signaling, was found to exhibit variable expression in glaucoma, which is associated with promoter methylation

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It has come to our attention that this is strongly connected to the three fundamental mechanisms of ferroptosis events: iron dyshomeostasis, oxidative damage caused by lipid peroxidation, and imbalance of the cellular antioxidant system (Yan and Zhang, 2019)