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People exposed to nitrous oxide (medical or recreational use) may develop functional B12 deficiency, as the gas inactivates B12-dependent enzymes, potentially requiring supplementation

J Am Chem Soc 118:96069614 Moroder L, Besse D, Musiol HJ, Rudolph-Bohner S, Siedler F (1996) Oxidative folding of cystine-rich peptides vs regioselective cysteine pairing strategies