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doi: 10.3389/fimmu.2017.00066 202 FrancisDMManspeakerMPSchudelASestitoLFO'MeliaMJKissickHT

Kim E-C, et al

For example, a detailed analysis of known ATF4 target genes in mouse liver showed that expression of ATF4 itself, Glutathione-specific gamma-glutamylcyclotransferase ( Chac1 ), DNA Damage Inducible Transcript 4 ( Ddit4 ), Eukaryotic initiation factor 4e binding protein 1 ( Eif4ebp1 ), Sestrin 2 ( Sesn2 ), Solute Carrier Family 7 Member 5 ( Slc7a5 ), and Tribbles homolog 3 ( Trb3 ) were increased after 6 h MR but to a lesser extent after 10 weeks on the MR diet (Fig