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The primary aim of coffee enemas, however, is not so much a bowel cleanse as to detoxify the liver and support liver function

Hsieh PS, Chen CW, Kuo YW, Ho HH

This may be along with general COX 1 and COX 2 specificity (24), with the pyloric sphincter less sensitive to COX 2 and the lower esophageal sphincter more sensitive, but ultimately both affected by inhibition of both COX 1 and COX 2