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Considering the correlation of the variant T allele with reduced GPX1 activity and the negative correlation of the total -SH levels with migraine attack duration, carriers of the T allele may experience longer attack duration due to reduced antioxidant capacity and thus reduced ability to neutralize oxidants possibly leading in prolonged migraine attacks

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Emerging evidence indicates limonoids confer neuroprotection in models of neurodegenerative diseases, including TBI (Mukherjee et al., 2019)