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A cross-sectional study involving 8,767 CKD patients demonstrated that sarcopenia increased the risk of death by 33%, reduced the 10-year survival rate by 4%, and doubled the risk of CKD progression to end-stage renal disease (ESRD) (41)

A co-IP experiment using HEK293T cells has shown association between TMEM106B and charged multivesicular body protein 2B (CHMP2B), a subunit of the endosomal sorting complex required for transport-III (ESCRT-III) [150]

A lack of energy can also disrupt these mechanisms

Thus, NRF2 regulation of redox based target genes must be fine-tuned to meet the functional demands of the stem cell given its dormant or more active state