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Sep 21 2017;377(12):1143-1155

N-terminal modifications and to a lesser extent C-terminal modifications, could improve the metabolic stability of Nle

Throughout both the latent and lytic phases, KSHV expresses genes that modulate the DDR by phosphorylating key proteins, including the tumor suppressor p53, and activating the ATM pathway 5,9,266,267

In general, increased lipophilicity has been suggested as a mechanism for enhancing intestinal uptake of drugs into the lymphatic system, thereby enhancing the entry of the conjugate into the brain and also thereby avoiding first-pass metabolism of the conjugate in the liver