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Tumor cells also release damage-associated molecular patterns (DAMPs) after IR, including high-mobility group box 1 (HMGB1), heat shock proteins (HSPs), and calreticulin (CRT), which mediate phagocytosis of antigen-presenting cells (APCs) and initiate tumor-specific T cell activation

Some people might feel a bit of vein irritation, but that's uncommon and typically mild