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Tolerance and digestive effects Common comments include issues of gastrointestinal tolerance (discomfort, nausea, diarrhoea) and, at high doses, the possible characteristic body odour described in some sources

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[3] [5] The International Olympic Committee (IOC) consensus statement on dietary supplements notes that only caffeine, creatine, buffering agents, and nitrate have good evidence of performance benefit, and none require IV administration