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Patients with status epilepticus (SE) had 37 elevated metabolites including pyruvate, quinolinic acid, and keto butyric acid levels with decreased levels of arginine, N-acetylaspartylglutamate (NAAG), tryptophan, uracil, and uridine 58

These mechanisms may have either direct effect on organelles like mitochondria, endoplasmic reticulum, the cytoskeleton, microtubules and nucleus or indirect effect on cellular organelles through the activation and inhibition of signalling kinases, transcription factors and gene-expression profiles

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Even short naps or a consistent evening wind-down routine can help lower oxidative stress levels