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These highly reactive molecules can damage cell membranes and proteins, which in turn can lead to premature ageing and cell damage

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Cardiovasc Res 36:276281 Masaki I, Yonemitsu Y, Yamashita A, Sata S, Tanii M, Komori K, Nakagawa K, Hou X, Nagai Y, Hasegawa M et al (2002) Angiogenic gene therapy for experimental critical limb ischemia: acceleration of limb loss by overexpression of vascular endothelial growth factor 165 but not of fibroblast growth factor-2

Hence, SOD-3 is a central virulence factor of and help to fungus survives under oxidative stress produced by host phagocytic cells during infection [64]