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In 2026, the average Part D deductible is $371 in MA-PDs, up 63% since 2025 ($228) and 481% since 2024 ($64) (Figure 7)

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The above phenomenon can be explained by the fact that the down-regulation of MITF expression will cause the down-regulation of TYR, TRP-1 and TRP-2, thereby inhibiting the synthesis of melanin, so the lower MITF expression will cause white plaques in patients with vitiligo

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