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102 It has a novel mode of action that is distinct from that of other tubulin inhibitors: it terminates microtubule elongation to trigger cell death with no effect on microtubule depolymerization

F.VenkatesanK.HaoT.Hirozane-KishikawaT.DricotA.LiN.et al (2005)

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Considering this and the evolutionary divergence of Nematoda, we hypothesise that diversification of CAT within metazoans is relatively recent compared to the long evolutionarily history of this enzyme