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Others, such as Vitamin D, are given separately for best absorption and safety

Enhanced Absorption : Formulated with Glutathione boosters such as N-acetyl cysteine (NAC) and Alpha Lipoic Acid (ALA) for improved absorption

It should be noted that the baseline vitamin B12 levels in this cohort were significantly higher than in the KEMU cohort ( p = 0.006), which may explain the faster exceeding of the vitamin B12 threshold

It reduces the activity of tyrosinase by three different mechanisms: (i) chelation of the copper site by its thiol group, (ii) interfering with the cellular transfer of tyrosinase to premelanosomes which is a prerequisite for melanin synthesis, and (iii) indirectly via its antioxidant effect.[] Glutathione shifts melanogenesis from eumelanin to phaeomelanin synthesis by reactions between thiol groups and dopa-quinone leading to the formation of sulfhydryl-dopa conjugates.[] It has also been found to be scavenger of UV radiation-induced reactive oxygen species generated in epidermal cells.[] METHODS This was a prospective comparative study to assess and compare the therapeutic efficacy of localized TA and glutathione for treatment of facial melasma over a period of 18 months (December 2017 to May 2019) conducted in department of dermatology on OPD basis in a tertiary care center